维吾尔_____肉豆蔻；抗肿瘤(期刊论文)

维吾尔药肉豆蔻抗肿瘤作用实验研究

http://www.100md.com 《新疆医科大学学报》 2005年第7期

维吾尔,,肉豆蔻；抗肿瘤,1材料与方法,2结果,3结论,参考文献：

     摘要：目的：探讨肉豆蔻种仁不同提取部位抗肿瘤的活性作用，为研究该药提供实验数据。方法：设计了2种提取方案，以系统溶剂法进行提取后，将2种方案中80%醇提浸膏以乙酸酯萃取，共得到13个提取部位，并以这13个提取部位作为受试样品，采用MTT比色法，分别对人白血病细胞系HL60、人胃癌细胞系BGC823、人乳腺癌系MDAMB435进行生长抑制实验；以细胞抑制率及IC50为指标，考查抗肿瘤活性。结果：经乙酸乙酯萃取后的乙酸乙酯可溶部分及方案一中的水提部位，对于上述细胞系的生长抑制效果较好。结论：经乙酸乙酯萃取后的乙酸乙酯可溶部分浸膏及及方案一中的水提部位具有明显的抗肿瘤效果。

    关键词：肉豆蔻；抗肿瘤

    Studies on the antitumor activity of Nutmeg

    ZHANG Jing, Rena, DU Niansheng, et al

    (Department of Pharmacognosy College of Pharmacy, Xinjiang Medical University, Urumqi 830054, China)

    Abstract: Objectives: To study on antitumor activity fractions of Nutmeg. Methods: We designed two extractive programme, and extracted with different solvents, then got 13 fractions. These fractions were tested for antitumor activity upon three kinds of tumor cells: HL60, BGC823, MDAMB435. Results: Based on the experimental result,It showed that EtOAc extracted fraction and water extracted fraction can inhibit three kinds of tumor cells growth. Conclution: Extracted fraction by EtOAc and water extracted fraction in programme have significant antitumor activity. ......

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